ORGANOGENESIS: Hyperthermia VS Antipyretic agents

A young woman in only the third week of her pregnancy develops a fever of 104°F but refuses to take any medication because she is afraid that drugs will harm her baby.

Is she correct?

WHY?

  1. Organogenesis; Hyperthermia VS Medications
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Professor
Professor
1 year ago

I don’t feel she’s entirely correct because the period of organogenesis begins from the 4th – 8th week of intrauterine development, hence the drugs won’t have a great impact acting as a teratogen. Also, if she’s ill an indication from her high fever, she should endeavor to take medication, as her unborn child won’t survive either if she died as a result of illness.
I would strongly suggest she takes drug substitutes which have none or the least teratogenic effect as prescribed by her physician.

Omowunmi
Omowunmi
1 year ago

First, No she isn’t correct in the sense that not all drugs will harm her baby though some might.
Second, her reasoning might have stemmed from the fact that the third week of pregnancy, also called the embryogenetic or critical period is the period of embryonic development and also a period when the embryo is most susceptible to the influence of teratogens. Teratogens are toxic substances that could also be in the form of drugs. They cause abnormalities or defects in the developing embryo known as teratomas. An example of a drug that uses to be administered as an antinauseant to pregnant women but isn’t anymore due to fatal side effects is Thalidomide. It worked like a teratogen leading to the loss of limbs in the embryo. Hence, some drugs might harm a developing embryo in the third week of pregnancy but not all will.

ulna bursitis
ulna bursitis
1 year ago

I think the pregnant woman is wrong, though her fears is due to the fact that some drugs used during pregnancy might affect the fetus..But in this case, antipyretics cannot induce teratogenesis..If she doesn’t use antipyretics,her fever would give hyperthermia (elevated temperature)which favors the formation of Spina bifida, anencephaly, cardiac and oral cleft defects

Mmhaliru
Mmhaliru
1 year ago

Yes, because fever doesn’t necessarily cause pregnancy loss, but may enhance the likelihood of congenital irregularities and autism.

It can also be a sign of an infection. And infections are more likely to cause pregnancy loss. Based on my perspective, I think she should contact her physician for a reasonable decision.

Joshua Godson
Joshua Godson
1 year ago

Yes she is correct.

During the third week of pregnancy the cells of the zygote undergo the process of cell division and multiply till an embryoblast is formed and the process of gastrulation begins.

The third to the eight week is usually referred to as the period of organogenesis in which the organs of the body develop. In this period the developing embryo is highly susceptible to several birth defects.

It is usually advised that all medications should be withdrawn during this period.

Studies of the effects of drugs on the embryo are mostly done using lab animals such as mouse or sheep but due to ethical reasons no direct studies are performed on the human embryo so it’s hard to tell how drugs affects the human embryo during this period.

Isaolamide
Isaolamide
1 year ago

Yes she maybe correct because many drugs are teratogenic which might cause congenital defect during the period of organogenesis (week3-8)

Me
Me
1 year ago

Yes, the woman is correct that the drugs may be teratogenic. A temperature as high as 104F (hyperthermia) is well known to cause spina bifida otherwise known as neural tube defects at this gestational stage (embryogenic or critical period). It is advisable to evaluate the risk of teratogenicity of an antipyretic drug (drugs used to reduce fever) and preferably settle for one with low teratogenic potential.

hafsat buba
hafsat buba
1 year ago

Nooo
Because fever can be cause by many factors been it viral or bacterial but a test is required to know what exactly cause the fever and the drugs that are prohibited mostly by pregnant women are aspirin and ibuprofen.