Thalidomide, an antinauseant and sleeping pill

The role of chemical agents and pharmaceautical drugs (medications) in the production of birth defect, congenital malformation and/or congenital anomaly in humans is difficult to assess.

Relatively few of the many drugs used during pregnancy have been positively identified as being teratogenic e.g thalidomide, an antinauseant and sleeping pill.

WHY?

Thalidomide, an antinauseant and sleeping pill

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Godwin
Godwin
1 year ago

This is due to the practical inability of drug researchers to try novel drugs on pregnant women as this is against regulatory polices… Furthermore in phase 4 trials( when the drug is in the market) doctors do not often report cases of adverse drug reaction to central monitoring bodies so the drug goes unchecked. This is my opinion

Professor
Professor
1 year ago

This is because the drug and other drugs too, interferes with the signalling pathways involved during the period of organogenesis (4th-8th week) of an embryo, especially that of the limbs leading to meromelia, amelia, phocomelia etc, it also affects other organs leading to heart, urinary system, ear and facial defects etc.

S.D
S.D
1 year ago

Teratogens are substances that may cause birth defects via a toxic effect on an embryo or fetus. Thalidomide is one of the taratogenic substance,Thalidomide causes birth defects. people using the drug should be advised of the risks and avoided in pregnancy; this applies to both men and women, as the drug can be transmitted in semen.

Mayor
Mayor
1 year ago

I believe scientists are yet to assess some chemical agents / drugs because of the unavailability of embryos to test on. Testing the effects of drugs on embryos will require them to perform prematured abortions.
And those who will intentionally leave their unborn babies for experiments are hard to come by.

That is my take on why it is difficult to assess the role of some drugs in anomaly.

Mayor
Mayor
Reply to  Support
1 year ago

Truth,thank you for the reply.

Adywap11
Adywap11
1 year ago

Well in my opinion the reason is because most drugs are not allowed to be used do clinical test on pregnant women..Also it is mostly in the 3rd-8th week during organogenesis that a drug can cause malformation so to monitor the effect of drugs during this periods is quite strenuous…. Even during pregnancy so women Vomit this reduces the concentration of the drugs that reaches the child and also increase in plasma level so it is quite difficult because this physiological changes affects the pharmacokinetics of the drugs

Mmhaliru
Mmhaliru
1 year ago

Because they cause severe limb defects such as Amelia and Meromilia

ulna bursitis
ulna bursitis
1 year ago

I think the drugs used by a pregnant woman during her gestational period can be many,so it’s quite difficult to extract enough information about them from her to predict their safety,and also,the time she was exposed to chemical agents matters,she might be able to give less information on this as well

Faith shulammite
Faith shulammite
1 year ago

Most teratogenic assays are done via embryological studies on rats or mice and it is difficult to carry out human trials because pregnant volunteers for clinical trials will be almost impossible to find… While it is true that the preclinical trials give a glimpse of the expected outcome in humans.. It does not completely tell for sure that same effect (teratogenic) would be seen in humans because it was seen in mice and due to specie differences. After teratogenic effect seen with thalidomide administration as antiemetic during pregnancy, serious restrictions and regulations were also placed on other drug candidates to be used during pregnancy. Basically one cannot specifically predict the effect of drugs on the embryo because clinical trials are rarely done on pregnant women