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    About TCA Cycle
    A. Acetyl CoA is produced from what substrates? (minimum of Three substrates)
    Biological Oxidation
    B. Give examples of high energy compounds (Minimum of Three)
    C. Mention Minimum of three activities taking place inside the Mitochondria
    About Heme
    D. (a)What is the rate limiting enzyme of heme synthesis (b)How is heme made water soluble?

    Khalid Mustapha

    A. 1.pyruvate
    2.fatty Acid
    3.keto genic amino acids
    C. 1.ATP generation
    2.TCA cycle
    3.Beta oxidation of fatty acids
    4.urea synthesis
    5.Electron transport chain
    D. a) ALA synthase (Amino Levulini acid synthase)
    b) The end product of catabolism of heme is bilirubin, which has no function in the body and is excreted through bile when transported to the liver. The liver cells plays the central role in the further disposal of bilirubin.The bilirubin which is formed in the reticuloendothelial cells in insoluble in water. It is therefore transported in plasma bound to albumin. When the albumin-biliruin complex reaches the sinusoidal surface of the liver, the bilirubin is taken up and it is being conjugated inside the liver with glucuronic acid to make it water soluble.

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